Unlike the typical imaging modalities employed for cancer diagnostics, ultrasound is real-time, portable, widely available and cost-effective. Adequate cancer diagnostics with ultrasound would have a global impact, giving access to clinical diagnostics even in low-income countries. This thesis aims at improving cancer diagnostics with ultrasound, focusing on two nonlinear ultrasound modalities: contrast-enhanced ultrasound (CE-US) and nonlinear parameter (B/A) imaging. CE-US is already utilized in the clinic to aid cancer diagnostics. B/A imaging is still under development and the utility of B/A has been poorly studied for cancer diagnostics.

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